Trans-10-hydroxy-2-decenoic acid alleviates LPS-induced blood-brain barrier dysfunction by activating the AMPK/PI3K/AKT pathway
M You, Z Miao, Y Pan, F Hu - European Journal of Pharmacology, 2019 - Elsevier
We previously reported that trans-10-hydroxy-2-decenoic acid (10-HDA), the exclusive lipid
component of royal jelly (RJ), alleviates Lipopolysaccharide (LPS)-induced
neuroinflammation both in vivo and in vitro. However, whether 10-HDA can protect against
LPS-induced blood-brain barrier (BBB) damage is largely unexplored. In this study, we first
observed that 10-HDA decreased BBB permeability in LPS-stimulated C57BL/6 mice by
Evan's blue (EB) dye. Immunostaining and Western blot results showed that 10-HDA …
component of royal jelly (RJ), alleviates Lipopolysaccharide (LPS)-induced
neuroinflammation both in vivo and in vitro. However, whether 10-HDA can protect against
LPS-induced blood-brain barrier (BBB) damage is largely unexplored. In this study, we first
observed that 10-HDA decreased BBB permeability in LPS-stimulated C57BL/6 mice by
Evan's blue (EB) dye. Immunostaining and Western blot results showed that 10-HDA …
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